Ferritin iron uptake and release. Structure–function relationships
نویسندگان
چکیده
منابع مشابه
Ferritin iron uptake and release. Structure-function relationships.
Iron uptake and release by ferritin molecules of different iron contents show similar profiles. These are discussed in relation to the structure of the ferritin molecule. Two models of iron uptake and release are considered. One involves iron oxidation-reduction sites on the protein. The other allows direct interaction of reagents with the iron-core crystallites. It is concluded that the second...
متن کاملUptake and Release of Ferritin Iron
The uptake and subsequent release of iron by apoferritin and ferritin was studied by using labelled iron (59Fe). The experimental results are consistent with predictions arising from amodel system developed in the interpretation ofprevious experiments. In thismodel, uptake and release of ferritin iron is controlled by the available surface area of the small crystalline particles of hydrous ferr...
متن کاملIron release and uptake by plant ferritin: effects of pH, reduction and chelation.
Ferritins are iron-storage proteins that accumulate in plastids during seed formation, and also in leaves during senescence or iron overload. Iron release from ferritins occurs during growth of seedlings and greening of plastids. Depending on the concentration of the reducing agent ascorbate, either an overall iron release or uptake by ferritins from iron(III) citrate may occur. We have designe...
متن کاملRelease of iron from ferritin by aceto- and benzohydroxamic acids.
The release of iron from ferritin by aceto- and benzohydroxamic acids was studied at two different iron chelator concentrations (100 and 10 mM), at two pH values (7.4 and 5.2), and in the presence or absence of urea. Collectively, the results demonstrate that both aceto- and benzohydroxamic acids remove iron from ferritin. Aceto- and benzohydroxamic acids penetrate the ferritin shell and react ...
متن کاملRelease of iron from ferritin requires lysosomal activity.
How ferritin-Fe becomes available for cell functions is unknown. Our previous studies with rat hepatoma cells indicated ferritin had to be degraded to release its Fe. In these studies, we investigated whether this occurs in other cell types and whether lysosomes are required. Release of ferritin-Fe was induced with desferoxamine (DFO) in (59)Fe-preloaded hepatoma, Caco2, and erythroid K562 cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1974
ISSN: 0264-6021
DOI: 10.1042/bj1430445